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Focused Interactions Important for Protein Dynamics

Jülich, 14 December 2016 - Many biological processes in cells function solely due to the phenomenon of diffusion. This ensures that particles are able to move randomly and aimlessly on the basis of their thermal energy alone. In this way, protein molecules get into close enough proximity to each other to, for example, carry out metabolic processes only achievable when acting together. A team of international researchers has now shown that weak attraction forces between proteins can enormously influence diffusion, if the protein molecules are as densely concentrated as under natural conditions in living cells.

Original publication:

Dramatic influence of patchy attractions on short-time protein diffusion under crowded conditions;
Saskia Bucciarelli, Jin Suk Myung, Bela Farago, Shibananda Das, Gerard Vliegenthart, Olaf Holderer, Roland G. Winkler, Peter Schurtenberger, Gerhard Gompper, Anna Stradner;
Science Advances 2: e1601432 (2016); DOI: 10.1126/sciadv.1601432

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