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BioSoft Colloquium:

Phase separation as an organizing principle in biology and disease

Simon Alberti

Professor of Cellular Biochemistry
Center for Molecular and Cellular Bioengineering (CMCB) and Biotechnology Center (BIOTEC) at Technische Universität Dresden, Germany

25 Feb 2021 11:00
Remote access

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We aim to understand how cells change their internal organization upon environmental perturbations, stress and aging. Many changes in stressed cells appear to directly result from alterations in the organization of the cytoplasm. Indeed, recent work from my lab and others shows that stressed cells form many membraneless compartments in the cytoplasm via a biochemical process known as phase separation.

Theoretical Physics Copyright: Prof. Alberti, Center for Molecular and Cellular Bioengineering (CMCB) and Biotechnology Center (BIOTEC) at Technische Universität Dresden, Germany

However, the initially beneficial ability to form such compartments becomes detrimental with increasing age, because compartment-forming tend to misfold and aggregate and thus are closely tied to aging and the pathogenesis associated with age-related diseases such as amyotrophic lateral sclerosis. Thus, recent efforts in the lab are focused on understanding the molecular links between cytoplasmic organization, membraneless compartments and age-related diseases.


Dr. Dmitry Fedosov
Phone: +49 2461 61-2972
Fax: +49 2461 61-3180