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Cell Engineering

By introducing and specifically targeting new proteins into cells, we aim to create systems that allow us to probe information processing in cell networks and generate new bioelectronic materials. Our current research is focused on:

Optogenetic Actuators

Optogenetic Actuators

Stimulation and inhibition of neuronal signaling using light actuated channels and pumps. Optogenetic actuators based on Channelrhodopsin, Halorhodopsin, and Photactivated adenyl cyclase are employed.

Genetically Encoded Voltage Indicators

Genetically Encoded Voltage Indicators

The membrane potential of the cell is monitored fluorescently using membrane associated proteins. Voltage changes are detected based on FRET or quenching of the inserted fluorophore.

Team

Dominik Brinkmann

Dominik Brinkmann, Doctoral Researcher

email:  do.brinkmann@fz-juelich.de
tel: +49 (0)2461 61 2343
Research activities: optogenetics, patterned neural networks, electrophysiology

Bogdana Cepkenovic

Bogdana Cepkenovic, Doctoral Researcher

email: b.cepkenovic@fz-juelich.de
tel: +49 (0)2461 61 3675
Research activities: MEA, neuronal networks, patch-clamp, calcium imaging

Vanessa Maybeck

Dr. Vanessa Maybeck, PI

email:  v.maybeck@fz-juelich.de
tel: +49 (0)2461 61 3285
Research activities: Engineered bioelectronic materials

Jiali Wang

Jiali Wang, Doctoral Researcher

email:  jia.wang@fz-juelich.de
tel: +49 (0)2461 61 6270
Research activities: optogenetics, electrophysiology, patterned neuronal networks

Ruoyan Wei

Ruoyan Wei, Doctoral Researcher

email: r.wei@fz-juelich.de
tel: +49 2461 61-2606
Research activities: Upconversion nanoparticles for optogenetic applications

Former Members

Timm Hondrich, Doctoral Researcher until 09/2020
Lucas Bertram, Master Student until 12/2019
Jana Schieren, Master Student until 03/2019
Irina Tihaa, Doctoral Researcher until 06/2018
Annika Graeve, Bachelor Student until 03/2018
Sarah Roßbiegalle, Bachelor Student until 02/2018
Wenfang Li, Doctoral researcher until 03/2017
Lei Jin, Doctoral Researcher until 07/2016







Additional Information

Contact:

Dr. Vanessa Maybeck

Tel.:  +49-2461-61-3285
e-mail: v.maybeck@fz-juelich.de

Recent Publication

Improvements of Microcontact Printing for Micropatterned Cell Growth by Contrast Enhancement, Hondrich et al., Micromachines 2019, 10, 659; doi:10.3390/mi10100659, https://www.mdpi.com/2072-666X/10/10/659

How to image cell adhesion on soft polymers? Seyock et al., Micron 2017, http://dx.doi.org/10.1016/j.micron.2016.11.002

Controlled Engineering of Oxide Surfaces for Bioelectronics Applications Using Organic Mixed Monolayers, Markov et al., ACS Applied Materials and Interfaces 2017 10.1021/acsami.7b08481,  https://pubs.acs.org/doi/abs/10.1021/acsami.7b08481

High-efficiency transduction and specific expression of ChR2opt for optogenetic manipulation of primary cortical neurons mediated by recombinant adeno-associated viruses, Jin  et al., J Biotechnol,2016, 233:171–80, https://doi.org/10.1016/j.jbiotec.2016.07.001

An evaluation of extracellular MEA versus optogenetic stimulation of cortical neurons
Maybeck et al., Biomed Phys Eng Express, 2016, 2:055017, https://doi.org/10.1088/2057-1976/2/5/055017



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