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Institute of Biological Information Processing
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The recording of (bio)-chemical signals from biological systems is a rich source to disclose information about the status of living matter, educts and products of biochemical processes, as well as the composition of the environment. We develop new concepts of electronic and electrochemical sensors for the detection of minute amounts of analyte molecules not only with high sensitivity and selectivity but also with high resolution in time and space.

Electrochemical sensors

Electrochemical sensors are widely used for disease diagnosis, to support medication, and for process monitoring. We aim to advance present sensor technology by investigating fundament aspect of charge transport in bio-inorganic hybrids, by the development of new receptor layers for analyte binding, and by introducing nanomaterials for signal amplification. Furthermore, we seek to convert promising sensor concepts to affordable sensor devices by utilizing printing fabrication methods. Our vision is to combine fundamental and applied research to develop high performance devices and versatile fabrication techniques for a broad accessibility of biosensors. 

Aptamer sensors

Aptamer sensors

DNA aptamer molecules can be utilized as receptor layer and substitute antibodies in modern biosensors. We develop new electrochemical aptamer sensors for reliable point of care detection of various biomarkers. Furthermore we aim to advance current receptor immobilization and signal amplification methods to enhance the sensor performance. More: Aptamer sensors …

Biochemical Sensors

Bio- and chemical sensors with enzymes and macrocycles and potentiometric sensors

Electrochemical (bio)sensors are prospective devices to achieve low detection limits and high selectivity for the quantification of (bio)chemical analytes due to catalytic reactions at electrodes and signal amplifications techniques. They may provide flexible, cost-effective, portable, and miniaturized multisensor arrays for biomedical research and implantable devices as well as for multianalyte environmental and technological process monitoring. More: Bio- and chemical sensors with enzymes and macrocycles and potentiometric sensors …

Printed Biosensors

Printed biosensors

Additive fabrication methods such as inkjet and 3D printing utilizing novel functional materials offer a way to manufacture low cost devices and sensors. These techniques do not rival but complement standard microfabrication approaches offering a compromise between cost and resolution, which is sufficient for many applications including chemical, physical and biological sensors. More: Printed biosensors …

Molecular Bioelectronics

Molecular bioelectronics

We develop single molecules and ensemble bio-electronic devices for the investigation and control of charge transport phenomena in and across biomolecules. These devices are operated at ambient conditions, in vacuum, and in liquids. The gained knowledge provides the basis for designing novel electronic devices and advancing electrochemical biosensors. More: Molecular bioelectronics …

Electronic sensors

We focus on the research and development of durable electronics, electronic sensors and actuators for environmental, bioelectronic, and biomedical applications. This includes (i) the development and characterization of suitable thin film compounds (e.g. complex oxide films or molecular layers), (ii) the preparation and optimization of micro- and nanosize electronic and electrochemical devices (e.g. field-effect transitors (FETs), metal electrode arrays (MEAs), break-junctions, and nanofluidic systems) and (iii) the development of various experimental technologies (ranging from microwaves and cryogenic to structural and surface analysis).

Our research encompasses the following topics:

Functional Oxide

Functional oxides

We focus on (i) the development of complex oxide thin film systems, (ii) the analysis, understanding and engineering of their physical and electronic properties, and (iii) their application in fields ranging from sensor devices to novel neuromorphic concepts. Special emphasis is placed on the physics of nanoscale  ferroelectric and/or conducting oxide systems. More: Functional oxides …

Molecular Layers

Molecular layers

Here we focus on the development and optimization of the deposition of organic layers and their use in sensor devices like FET or SAW. In-situ activation and in-situ monitoring allows a perfect control of the deposition process of a single SAM, mixed molecular layers or multilayers and the electronic characterization of the layers during the growths. More: Molecular layers …


Microelectrode arrays

Micro electrode arrays (MEA) for bio sensing applications combine the advantages of a large total active area, which enables the detection of small amounts of biomolecules, with a small area and therefore low noise characteristics, which permits the detection of even very weak signals. Our MEAs consist of 64 individually and simultaneously assessable electrodes.Nanowire/Graphene FETs More: Microelectrode arrays …

NanowireGraphene FETs

Nanowire/Graphene FETs

Low-dimensional systems and nanoscaled devices represent key structures for detection of ultra-small signals of biological objects due to increased surface-to-noise ratio. We develop field –effect transistor (FET) structures with new functionality providing fast and sensitive signal transduction from biomaterials aiming the realization of new generation of diagnostic platform. More: Nanowire/Graphene FETs …

Microwave microfluidic sensors

Microwave microfluidic sensors

Studies of biochemical liquids require precise determination of their complex permittivity. However, the challenge becomes more complex for evaluating the electromagnetic parameters when small amounts of substances have to be tested. We are developing novel approaches for supplying, positioning and testing bioliquids, using microwave resonator technique. More: Microwave microfluidic sensors …

Magnetic field sensors

We develop superconducting quantum interference devices (SQUID) as ultra-sensitive magnetic sensors for biomedical sensing. Our focus is put on applications of high-Tc SQUIDs for low field nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI), on magnetic nanoparticle detection and on biomagnetism.

Low field nuclear magnetic resonance

Low field NMR

Nuclear magnetic resonance at low magnetic field is a very promising technique for analyzing the structure of molecules. At low field, the coupling of nuclei can be favorably studied. We are working towards low field MRI for diagnostic purposes. The use of magnetic nanoparticles as contrast agents is examined. More: Low field NMR …

Magnetic Particle Actuation

Magnetic particle actuation

We set up multi-pole electromagnetic tweezers to manipulate magnetic particles in 2D/3D. In Magnetic Twisting Cytometry (MTC) mode, the device can be used to efficiently measure the mechanical properties of living cells. More: Magnetic particle actuation …

Magnetic Particle Detection

Magnetic particle sensing

Our research is aimed at developing magnetic assays for sensitive detection of proteins and viruses using frequency mixing magnetic detection of magnetic beads which act as selective markers for the analyte. More: Magnetic particle sensing …