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Pathways of protein folding

  • How does an unfolded, useless protein get into the (cell) membrane and does suddenly obtain its important function, such as regulation of blood pressure or appetite?
  • And how does a harmless and useful protein end up in a state that causes severe damage to neuronal cells, which is linked to Alzheimer's or Parkinson's disease?

We are developing and applying new approaches to obtain high-resolution insights into these challenging questions. We are in particular interested in the structural and kinetic details which underlay and/or determine the pathways of membrane protein folding and amyloid fibril formation.

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