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A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism
S. G. Kathman, I. Span, A. T. Smith, Z. Xu, J. Zhan, A. C. Rosenzweig, A. V. Statsyuk, J. Am. Chem. Soc. 2015, 137 (39), 12442-5.

Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH
I. Span, K. Wang, W. Eisenreich, A. Bacher, Y. Zhang, E. Oldfield, M. Groll, J. Am. Chem. Soc. 2014, 136 (22), 7926-32.

Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH
I. Span, K. Wang, W. Wang, J. Jauch, W. Eisenreich, A. Bacher, E. Oldfield, M. Groll, Angew. Chem. Int. Edit. 2013, 52 (7), 2118-21.

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH
I. Span, K. Wang, W. Wang, Y. Zhang, A. Bacher, W. Eisenreich, K. Li, C. Schulz, E. Oldfield, M. Groll, Nat. Commun. 2012, 3, 1042.

Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation
W. Wang, K. Wang, I. Span, J. Jauch, A. Bacher, M. Groll, E. Oldfield, J. Am. Chem. Soc. 2012, 134 (27), 11225-34.

Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate’s Hydroxymethyl Group during Catalysis
I. Span, T. Gräwert, A. Bacher, W. Eisenreich, M. Groll, J. Mol. Biol. 2012, 416 (1), 1-9.

Reductive dehydroxylation of allyl alcohols by IspH protein
T. Gräwert, I. Span, A. Bacher, M. Groll, Angew. Chem. Int. Edit. 2010, 49, 8802-8809.

Probing the reaction mechanism of IspH protein by x-ray structure analysis
T. Gräwert, I. Span, W. Eisenreich, F. Rohdich, J. Eppinger, A. Bacher, M. Groll, Proc. Natl. Acad. Sci. U. S. A. 2010, 107 (3), 1077-1081.

Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction
T. Gräwert, F. Rohdich, I. Span, A. Bacher, W. Eisenreich, J. Eppinger, M. Groll, Angew. Chem. Int. Edit. 2009, 48, 5756-5759.