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Solid-State NMR group

Solid-State NMR group
Head: Prof. Dr. Henrike Heise

Heise Gruppenbild

In recent years, solid-state NMR-spectroscopy has become an important method for Structural Biology. It is particularly valuable for the structural determination of systems that are neither crystallizable nor soluble, e.g. membrane proteins embedded in lipid bylayers or protein aggregates. The Department of Biomolecular Solid State NMR Spectroscopy is developing new approaches to harness the methods full potential. At the Biomolecular NMR Center, which is jointly run Heinrich-Heine University Düsseldorf and Forschungszentrum Jülich, state of the art solid-state NMR spectrometers operating at 600 and 800 MHz are available.

One of the most demanding challenges of NMR spectroscopy is the inherently low sensitivity. Signal enhancement by DNP is a promising alternative to gain insights into systems which otherwise could not be investigated. In 2014, a 600 MHz DNP-NMR spectrometer was installed (see picture, Foto Ralf-Uwe Limbach). The installation of an 800 MHz DNP-NMR is scheduled for 2015. We will exploit the technique to obtain structural information on complex systems (protein aggregates, and membrane proteins in lipid bilayers) which otherwise would be inaccessible to structural investigations. Furthermore, the possibilities of this technique for selective enhancement will be exploited.