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Biophysics of Protein Interactions

Interactions of proteins with other proteins, ligands or membranes are crucial in disease related processes. Using liquid state NMR we study structural aspects, map binding sites and determine affinity constant of such interactions. Thermodynamic parameters are derived from surface plasmon resonance, isothermal titration calorimetry and microscale thermophoresis. Membrane proteins are studied in model membranes, e.g., liposomes, nanodiscs, or detergent micelles. Our specific research areas are:

HIV-1 VpU and human CD4

König 1

Interaction of Dengue Virus protein NS4A with membranes

NS4A DenV

Nanodiscs – a superior model membrane

König 2


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