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Publications 2014

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Hepatitis C virus NS5A is able to competitively displace c-Myc from the Bin1 SH3 domain in vitro
Journal of peptide science 20(5), 334 - 340 () [10.1002/psc.2618]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Analysis of the Bin1 SH3 interaction with peptides derived from the hepatitis C virus protein NS5A and c-Myc reveals that NS5A can competitively displace c-Myc in vitro
1st International Conference of Collaborative Research Center 974: Liver Damage and Regeneration, DüsseldorfDüsseldorf, Germany, 15 Nov 2014 - 16 Nov 20142014-11-152014-11-16 OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Early amyloid β-protein aggregation precedes conformational change
Chemical communications 50(40), 5373-5375 () [10.1039/c3cc48704k] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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A Kinetic Approach to the Sequence–Aggregation Relationship in Disease-related Protein Assembly
The journal of physical chemistry <Washington, DC> / B 118(4), 1003 - 1011 () [10.1021/jp412648u]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Protein misfolding, membrane interactions and paramagnetism studied by solid state NMR spectroscopy
EMBO Workshop on Magnetic Resonance for Celular Structural Biology, Principina Terra (Grosetto)Principina Terra (Grosetto), Italy, 1 Jun 2014 - 6 Jun 20142014-06-012014-06-06 BibTeX | EndNote: XML, Text | RIS

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Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6
The FEBS journal 281(10), 2471 - 2483 () [10.1111/febs.12800]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Low-dose X-ray radiation induces structural alterations in proteins
Acta crystallographica / D 70(10), 2675 - 2685 () [10.1107/S1399004714017295]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Extension of the FACTS Implicit Solvation Model to Membranes
Journal of chemical theory and computation 10(8), 3163 - 3176 () [10.1021/ct500084y]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly
Journal of structural biology 188(3), 249–258 () [10.1016/j.jsb.2014.10.002]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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A mirror-phage display selected D-peptide and its derivative eliminate Abeta oligomers in vitro and decelerate cognitive and motoric impairments of transgenic AD mice in vivo
Neurovisionen 10 conference, JülichJülich, Germany, 26 Sep 2014 - 26 Sep 20142014-09-262014-09-26 OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Immobilization of Homogeneous Monomeric, Oligomeric and Fibrillar Aβ Species for Reliable SPR Measurements
PLoS one 9(3), e89490 (1 - 7) () [10.1371/journal.pone.0089490] OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Kinetic Titration Series with Biolayer Interferometry
PLoS one 9(9), e106882 () [10.1371/journal.pone.0106882] OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Detection and Quantitation of Amyloid-β Aggregates in Body Fluids may be Suitable for Early Diagnosis of Alzheimer’s Disease
Advances in Alzheimer's Research Indianapolis, USA : BENTHAM SCIENCE PUBLISHERS 275 - 290 ()   Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein
Protein engineering design and selection 27(12), 473-479 () [10.1093/protein/gzu047]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Alternative Conformations of the Tau Repeat Domain in Complex with an Engineered Binding Protein
The journal of biological chemistry 289(33), 23209 - 23218 () [10.1074/jbc.M114.560920]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Expression and purification of soluble HIV-2 viral protein R (Vpr) using a sandwich-fusion protein strategy
Protein expression and purification 95, 156-161 () [10.1016/j.pep.2013.12.007]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Protein Structure Prediction: Assembly of Secondary Structure Elements by Basin-Hopping
ChemPhysChem 15(15), 3378–3390 () [10.1002/cphc.201402247]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Pharmakokinetic properties of D-peptides developed to be therapeutically active against beta-amyloid oligomers
NeuroVisionen 10, JülichJülich, Germany, 26 Sep 2014 - 26 Sep 20142014-09-262014-09-26 OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Recombinant Production of the Amino Terminal Cytoplasmic Region of Dengue Virus Non-Structural Protein 4A for Structural Studies
PLoS one 9(1), e86482 (1 - 10) () [10.1371/journal.pone.0086482] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Structure and membrane interaction of the N-terminal region of Dengue virus NS4A protein
Annual Meeting of the German Biophysical Society, LübeckLübeck, Germany, 14 Sep 2014 - 17 Sep 20142014-09-142014-09-17 BibTeX | EndNote: XML, Text | RIS

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Preclinical pharmakokinetic studies of tritium labelled D-Enantiomeric Peptide D3 in mouse models
Neurovisionen 10, JülichJülich, Germany, 26 Sep 2014 - 26 Sep 20142014-09-262014-09-26 OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Characterization of D-enatiomeric peptides derived from D3 for treatment of Alzheimer`s disease
Alzheimer`s Association International Conference 2014, CopenhagenCopenhagen, Denmark, 13 Jul 2014 - 13 Jul 20142014-07-132014-07-13 OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1
Nature Communications 5, (1-10) 4106 () [10.1038/ncomms4106] OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Expression and Purification of Membrane Proteins
New York, NY [u.a.] : Elsevier, Methods in enzymology 541, 117-140 () [10.1016/B978-0-12-420119-4.00010-0] BibTeX | EndNote: XML, Text | RIS

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Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Cell 156(6), 1193 - 1206 () [10.1016/j.cell.2014.02.008]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Probing transient conformational States of proteins by solid-state R$_{1ρ}$ relaxation-dispersion NMR spectroscopy
Angewandte Chemie / International edition 53(17), 4312-4317 () [10.1002/anie.201311275]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Sequestration of a β-Hairpin for Control of α-Synuclein Aggregation
Angewandte Chemie / International edition 53(16), 4227-4230 () [10.1002/anie.201309001]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide
Journal of biotechnology -, S0168-1656(14)00287-9 () [10.1016/j.jbiotec.2014.06.006]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Conformational dynamics of the autophagy-related protein GABARAP on multiple time-scales
EUROMAR 2014, ZürichZürich, Schweiz, 29 Jun 2014 - 3 Jul 20142014-06-292014-07-03  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Progress towards structural understanding of infectious sheep PrP-amyloid
Prion 8(5), 344-358 () [10.4161/19336896.2014.983754]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism
Nature Communications 5, 1-10 () [10.1038/ncomms5169] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Amyloid Aggregation Inhibitory Mechanism of Arginine-rich D-peptides
Current medicinal chemistry 21, 1448-1457 ()  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Identifizierung von artifiziellen Liganden eines in Nanodiscs inkorporierten integralen Membranproteins
Jülich : Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag, Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies 80, 106 pp () = Univ. Düsseldorf, Diss., 2013 OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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High-resolution structure of a membrane protein transferred from amphipol to a lipidic mesophase.
The journal of membrane biology 247(9-10), 997 - 1004 () [10.1007/s00232-014-9700-x]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Nanoparticle surface-enhanced Raman scattering of bacteriorhodopsin stabilized by amphipol A8-35
The journal of membrane biology 247(9-10), 971 - 980 () [10.1007/s00232-014-9701-9]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Solution NMR study of the interaction of HIV-1 VpU and human BST-2
Annual Meeting of the German Biophysical Society, LübeckLübeck, Germany, 14 Sep 2014 - 17 Sep 20142014-09-142014-09-17 BibTeX | EndNote: XML, Text | RIS

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Characterization of D-enantiomeric peptides binding to monomeric Amyloid beta (1-42) identified by a competitive mirror image phage display
Alzheimer`s Association International Conference 2014, CopenhagenCopenhagen, Denmark, 13 Jul 2014 - 13 Jul 20142014-07-132014-07-13 OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Deformable elastic network refinement for low-resolution macromolecular crystallography
Acta crystallographica / D 70(9), 2241 - 2255 () [10.1107/S1399004714016496] BibTeX | EndNote: XML, Text | RIS

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The non-structural protein 5A (NS5A) of hepatitis c virus interacts with the SH3 domain of human Bin1 using non-canonical binding sites
1st International, DüsseldorfDüsseldorf, Germany, 15 Nov 2014 - 16 Nov 20142014-11-152014-11-16 OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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The autophagy-related protein GABARAP directly interacts with the anti-apoptotic regulator BcI-2
Gordon Research Conference: Autophagy in Stress, Development & Disease, Il CioccoIl Ciocco, Italy, 16 Mar 2014 - 21 Mar 20142014-03-162014-03-21 BibTeX | EndNote: XML, Text | RIS

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Crystal Structure of Escherichia coli-Expressed Haloarcula marismortui Bacteriorhodopsin I in the Trimeric Form
PLoS one 9(12), e112873 () [10.1371/journal.pone.0112873] OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Protein-Protein Interactions in Drug Discovery. Edited by Alexander Dömling.
Protein–Protein Interactions in Drug Discovery. Edited by Alexander Dömling. ChemBioChem 15(3), 472 - 473 () [10.1002/cbic.201300761]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the C-terminal domain of Par-4 (PAWR)
Acta crystallographica / F 70, 1224 - 1227 () [10.1107/S2053230X14014691]  Download fulltext Files  Download fulltextFulltext BibTeX | EndNote: XML, Text | RIS

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Solid State NMR Spectroscopy: Investigation of the core arrangement in the prion domain of Sup35NM S17R mutant
GDCh-Fachtagung "Magnetische Resonanzspektroskopie", BerlinBerlin, Germany, 29 Sep 2014 - 2 Oct 20142014-09-292014-10-02 BibTeX | EndNote: XML, Text | RIS

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Solid state NMR on recombinant fibrillar hIAPP for site specific resonance assignments
GDCh-Fachgruppentagung "Magnetische Resonanzspektroskopie", BerlinBerlin, Germany, 29 Sep 2014 - 2 Oct 20142014-09-292014-10-02 BibTeX | EndNote: XML, Text | RIS

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The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
AIDS research and therapy 11(1), 1 - 7 () [10.1186/1742-6405-11-1] OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Liposome Reconstitution and Modulation of Recombinant Prenylated Human Rac1 by GEFs, GDI1 and Pak1
PLoS one 9(7), e102425 () [10.1371/journal.pone.0102425] OpenAccess  Download fulltext Files  Download fulltextFulltext Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS


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