Brain Collection Prof. Zilles

Brain Collection Stephan

Cytoarchitecture linked to gene expression to study multilevel human brain organization

Decoding the chain from genes to cognition requires detailed insights how areas with specific gene activities and microanatomical architectures contribute to brain function and dysfunction. The Allen Human Brain Atlas contains regional gene expression data, while JuBrain Atlas offers three-dimensional cytoarchitectonic maps reflecting interindividual variability. To date, an integrated framework that combines the analytical benefits of both scientific platforms towards a multi-level brain atlas of adult humans was not available. We have therefore developed JuGEx, a new method for integrating tissue transcriptome and cytoarchitectonic segregation.

The JuGEx workflow and the GUIs are based on a script distribution that was coded in Matlab (version R2015b, 64bit).

Funding:
This research was supported by the European Union Seventh Framework program (FP7/2007-2013) Grant 604102 (Human Brain Project) to K.A. and S.C.

Reference:
Sebastian Bludau, Thomas W. Mühleisen, Simon B. Eickhoff, Michael J. Hawrylycz, Sven Cichon, Katrin Amunts. Integration of transcriptomic and cytoarchitectonic data implicates a role for MAOA and TAC1 in the limbic-cortical network. 2018, Brain Structure and Function. https://doi.org/10.1007/s00429-018-1620-6

PaMiNI (Pattern Mining in NeuroImaging) is a novel coordinate-based meta-analytic approach for finding frequent co-activation patterns within neuroimaging datasets. The zip file contains the files of the implemented MATLAB software.

Caspers J, Zilles K, Beierle C, Rottschy C, Eickhoff SB. 2013. A novel meta-analytic approach: Mining frequent co-activation patterns in neuroimaging databases. NeuroImage, in revision.

Combining probabilistic cytoarchitectonic maps and functional imaging data

(Version: 1.8)

Combining probabilistic cytoarchitectonic maps and functional imaging data

Combining probabilistic cytoarchitectonic maps and functional imaging data

(Version: 2.2)

Combining probabilistic cytoarchitectonic maps and functional imaging data

(Version: 2.2c)