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Alcohol-Enhanced Cu-Mediated Radiofluorination

The potential of many 18F- labeled (hetero)aromatics for applications in positron emission tomography remains underexplored because convenient procedures for their radiosynthesis are lacking. Consequently, simple methods to prepare radiofluorinated (hetero)arenes are highly sought after. Herein, we report the beneficial effect of primary and secondary alcohols on Cu-mediated 18F-labeling.This observation contradicts the assumption that such alcohols are inappropriate solvents for aromatic fluorination.

J. Zischler, N. Kolks, D. Modemann, B. Neumaier, B. D. Zlatopolskiy, Chem. - Eur. J. 2017, 23, 3251-3256
DOI: 10.1002/chem.201604633.

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