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Novel CDTA-based, Bifunctional Chelators for Stable and Inert MnII Complexation

The synthesis of two CDTA-based bifunctional MnII chelators (BFMnCs) reactive in “click” chemistry is reported. A “click” conjugate of one BFMnC was used to perform a detailed thermodynamic, kinetic, and relaxometric assessment of the corresponding MnII complex. As demonstrated by the exquisite balance between thermodynamic stability, kinetic inertness, and relaxivity of the chelate, the reported BFMnCs are promising precursors for MnII-based PET/MR tracers (52g/55MnII) as well as MR contrast agents (MnII) of the next generation.

bifunktionelle chelatoren / bifunctional chelators

C. Vanasschen, E. Molnár, G. Tircsó, F.K. Kálmán, É. Tóth, M. Brandt, H.H. Coenen, B. Neumaier, Novel CDTA-based, Bifunctional Chelators for Stable and Inert MnII Complexation: Synthesis and Physicochemical
Characterization, Inorg. Chem. 56, 7746(2017); [doi:10.1021/acs.inorgchem.7b00460].

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