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Discovery of 7‑[18F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo

Tryptophan and its metabolites are involved in different physiological and pathophysiological processes. Consequently, positron emission tomography (PET) tracers addressing tryptophan metabolic pathways should allow the detection of different pathologies like neurological disorders and cancer. Herein we report an efficient method for the preparation of fluorotryptophans labeled in different positions with 18F and their biological evaluation.

B. D. Zlatopolskiy, J. Zischler, D. Schäfer, E. A. Urusova, M. Guliyev, O. Bannykh, H. Endepols, B. Neumaier, J. Med. Chem. 2018, 61, 189-206,
DOI: 10.1021/acs.jmedchem.7b01245.

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